NF-κB regulates Lef1 gene expression in chondrocytes
K Yun, YD Choi, JH Nam, Z Park, SH Im - Biochemical and biophysical …, 2007 - Elsevier
The relation of Wnt/β-catenin signaling to osteoarthritis progression has been revealed with
little information on the underlying molecular mechanism. In this study we found
overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular
mechanism of NF-κB-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1β
augmented Lef1 upregulation and nuclear translocation of NF-κB in chondrocytes. Under IL-
1β signaling, treatment of NF-κB nuclear translocation inhibitor SN-50 reduced Lef1 …
little information on the underlying molecular mechanism. In this study we found
overexpression of Lef1 in cartilage tissue of osteoarthritic patients and elucidated molecular
mechanism of NF-κB-mediated Lef1 gene regulation in chondrocytes. Treatment of IL-1β
augmented Lef1 upregulation and nuclear translocation of NF-κB in chondrocytes. Under IL-
1β signaling, treatment of NF-κB nuclear translocation inhibitor SN-50 reduced Lef1 …
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